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What is Sermorelin?  Why choose Sermorelin?  Common questions...we have the answers! 

Thursday
16Apr2009

I’ve heard that GHRT using recombinant hGH is “non-physiologic” and actually causes the hGH neuroendocrine system to malfunction. Is this true or not and can you explain the difference between physiological and non-physiological (or pharmacological) GHRT?

Yes, it is true that use of recombinant hGH for GHRT is a pharmacological approach that brings the benefits intended on body composition (reduced fat and increased lean body mass [muscle]. However, because it...

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Thursday
16Apr2009

Sometimes we initially see IGF-1 decrease when secretagogues such as sermorelin are administered to patients. If sermorelin stimulates somatotroph production and secretion of hGH which in turn is supposed to cause IGF-1 to go up, how can you explain the paradoxical drop in circulating IGF-1?

The reported decrease in IGF-1 following secretagogue administration has been attributed to multiple potential causes ranging from poor pituitary reserve to hepatic insensitivity to hGH. These are probably accurate...

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Thursday
16Apr2009

Are all secretagogues the same and are they used in hGH replacement therapy (GHRT) in aging?

No, they are not all the same and yes they are preferred for GHRT over recombinant hGH. There are 3 general categories of growth hormone secretagogues that have different loci of action. The secretagogues either...

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Thursday
16Apr2009

Are growth hormone secretagogues the same thing as growth hormone and if not how are they different?

Growth hormone (GH) or somatotrophin is a hormone produced by the pituitary gland that contains 191 amino acids and functions as its proper name (somatotrophin) implies as a trophic substance to the soma or body...

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Tuesday
17Mar2009

What is Sermorelin?

Sermorelin is a form of GRF that contains only the first 29 amino acids. GRF that is produced by neurosecretory neurons in the brain contains 44 amino acids.

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Tuesday
17Mar2009

Is Sermorelin the same as human growth hormone (hGH)?

No, it is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete hGH.

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Tuesday
17Mar2009

Are OTC "GH supplements" the same as Sermorelin?

No, the OTC secretagogues or releasers are usually the amino acids L-arginine, L-glutamine, L-ornithine, glycine, L-dopa, as well as such substances as ornithine alpha-ketoglutarate and the herbs Macuna pruriens and Tribulus terrestris.

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Tuesday
17Mar2009

Why prescribe Sermorelin over GH for AGHD?

For several reasons including the fact that it produces the same effects on body composition and other benefits of hGH but in addition:

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Tuesday
17Mar2009

Must Sermorelin be injected just as for hGH?

Currently, the only method for effectively administering Sermorelin is by subcutaneous injection.

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Tuesday
17Mar2009

Are the dosages of hGH and Sermorelin comparable?

Although the molecules work at different sites in the body, the amount of material needed to be effective in raising serum IGF-1 are approximately the same.

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Tuesday
17Mar2009

Are the doctor's costs for hGH and Sermorelin comparable?

Costs of Sermorelin per vial is about 10 – 15% less expensive than hGH.

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Tuesday
17Mar2009

Do you have to cycle Sermorelin?

Loss of hGH potency after about six months or more of continuous use is not unusual and is not due to inferior product.

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Tuesday
17Mar2009

Does Sermorelin have any non-endocrine effects that may be useful in treating aging clients?

Yes. There are many reports of data in peer-reviewed medical and scientific journals showing that GRF/Sermorelin also has a direct effect on the brain to promote non-REM slow wave sleep.

Tuesday
17Mar2009

Is there a standard protocol for prescribing Sermorelin?

Dose selection should be suited for each person's individual needs. However, guidelines for dosing are:

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